🍇 Resveratrol and Pterostilbene: Comparison, Longevity and Sirtuins
Two stilbenes linked to longevity - let's look at the differences and the data
Resveratrol and pterostilbene are natural compounds (stilbenes) linked to longevity and sirtuin activation. They are often compared when choosing a supplement. Let's look at the differences and what the data show.
Both compounds are interesting, but differ in bioavailability and effects. Let's look at the mechanisms, comparison and limits of evidence.
What are stilbenes
Stilbenes are plant compounds. Resveratrol and pterostilbene are studied for antioxidant properties and a link to longevity.
Sirtuins
Sirtuins are proteins linked to metabolism and longevity. Resveratrol is linked to their activation.
Comparison
Resveratrol and pterostilbene differ.
| Compound | Bioavailability | Studied |
|---|---|---|
| Resveratrol | Low | More studied |
| Pterostilbene | Higher | Less studied |
Bioavailability
Bioavailability is a key difference between these compounds.
Sources
Sources of the compounds.
| Compound | Sources |
|---|---|
| Resveratrol | Red grapes, red wine, berries |
| Pterostilbene | Blueberries, grapes |
Data and limits
It is important to understand the limits of data on stilbenes.
What matters
How to sensibly approach resveratrol and pterostilbene.
Assess the goal
Resveratrol is better studied, pterostilbene absorbs better.
Berries and grapes
Sources of stilbenes in the diet. Doses in food are lower than in supplements.
Proven supplements
If choosing a supplement, pay attention to the form and dosage.
Not a "panacea"
Data on aging are limited. Stilbenes are part of a healthy lifestyle. More in the article on sirtuins.
What is resveratrol?
A natural stilbene (in grapes, berries) studied for antioxidant properties and a link to sirtuins.
How does pterostilbene differ from resveratrol?
Pterostilbene (methylated) absorbs better and lasts longer. Resveratrol is better studied.
Does resveratrol help extend life?
Data on "extending life" in humans are limited. Many effects are shown in animals and in the lab.
What are sirtuins?
Proteins linked to metabolism and longevity. Resveratrol is studied as their activator (e.g., SIRT1).
Which foods provide stilbenes?
Resveratrol - red grapes, red wine, berries. Pterostilbene - blueberries, grapes.
Which is better: resveratrol or pterostilbene?
Depends on the goal. Resveratrol is better studied, pterostilbene absorbs better.
Are stilbene supplements needed?
Supplements give higher doses than food. The need depends on goals and condition.
Are stilbenes safe?
At recommended doses usually yes. With medications and conditions - a doctor's consultation.
Do stilbenes slow aging?
Data are limited and mostly from animals. In humans, evidence of "slowing aging" is insufficient.
How to choose a stilbene supplement?
By goal and composition. Pay attention to the form and dosage. Consult a doctor.