Longevity Science: Extending Healthspan
Alpha-ketoglutarate (AKG) is a key molecule of the Krebs cycle studied in the context of longevity and reducing biological age. We break down the mechanisms, forms and dosages.
Senescent (aging) cells and 'zombie cells': how senolytics cleanse the body. Mechanism, candidates (dasatinib, quercetin, fisetin), stages of research.
Theories of aging: why we age from a biological standpoint. Telomeres, free radicals, mitochondria, epigenetics, senescent cells — what is proven and what really helps slow aging.
The geroscience paradigm proposes treating ageing as the common root of age-related diseases. We break down how this approach changes prevention and what role nutraceuticals play.
Epigenetics of aging: how lifestyle and diet affect gene expression. DNA methylation mechanisms, sirtuins, practical significance for longevity.
Caloric restriction (CR) and caloric restriction mimetics (CRM): why it works, what is known about metformin, berberine and rapamycin, their mechanisms, risks and what is proven in humans.
Exploring the science of longevity. Molecular mechanisms of aging and evidence-based methods to extend healthspan.
Senolytics, NAD+ therapy, geroprotectors, intermittent fasting — only peer-reviewed data.