⏳ Alpha-Ketoglutarate (AKG and AKG-Ca): Reducing Biological Age
How an energy-cycle molecule is studied in the context of rejuvenation
Alpha-ketoglutarate (AKG) is a key molecule of the Krebs cycle involved in energy metabolism. Recent research studies its link to reducing biological age and supporting longevity. Let's look at what is known.
What is AKG
Alpha-ketoglutarate is an organic acid, a central intermediate of the Krebs cycle. It participates in energy production, amino acid metabolism and as a cofactor in reactions. In recent years it has been studied in the context of longevity.
- Central molecule of the Krebs cycle.
- Participates in energy production.
- Cofactor in amino acid metabolism.
- Studied for longevity.
Role in the Krebs cycle
The Krebs cycle is the central pathway of energy production in mitochondria. AKG is a key intermediate that feeds the electron transport chain and ATP synthesis.
- Key compound of the Krebs cycle.
- Feeds the electron transport chain.
- Participates in ATP synthesis.
- Links energy and metabolism.
AKG and ageing
Animal studies and early human data examine the link between AKG and reducing biological age and improving health in older age. Mechanisms include mitochondrial support, methylation and metabolism.
- Studied for reducing biological age.
- Mitochondrial support.
- Effect on methylation.
- Early data promising, but research needed.
Forms AKG and AKG-Ca
| Form | Feature | Use |
|---|---|---|
| AKG (free) | Base acid | Energy |
| AKG-Ca (calcium salt) | Stable form | Longevity, research |
Food: sources
AKG is found in food in small amounts and is mostly synthesised in the body from other metabolites. Therefore it is studied as a supplement, not from food.
| Food | Content | Comment |
|---|---|---|
| Meat | Trace amounts | From glutamate |
| Vegetables | Low | From glutamine |
Dosages
| Indicator | Value | Comment |
|---|---|---|
| Typical dose | 1–2 g/day | AKG-Ca |
| Course | 8–12 weeks | In studies |
Practice
- AKG is an experimental longevity direction.
- AKG-Ca is more often used in research.
- Take per label in courses.
- Does not replace lifestyle and diet.
- Consult a doctor.
What is alpha-ketoglutarate?
An organic acid, a key intermediate of the Krebs cycle.
How is AKG linked to ageing?
Studied for its link to reducing biological age and supporting metabolism.
What is AKG's role in the Krebs cycle?
Feeds the electron transport chain and participates in ATP synthesis.
How does AKG-Ca differ from AKG?
AKG-Ca is a stable calcium salt, more often used in longevity research.
How much AKG to take?
Usually 1–2 g a day, for 8–12 weeks, per the label.
Is there AKG in food?
Trace amounts in food; mostly synthesised in the body.
Is age reduction proven in humans?
Human data are still limited; most comes from animals.
Is AKG safe?
Generally well tolerated, but research continues.
Does AKG replace lifestyle?
No, it is a supplement; the base is diet, sleep and activity.
Which form to choose?
AKG-Ca is more often used in longevity research.