🌿 Clinical Trials of Ashwagandha (KSM-66 / Sensoril): Cortisol and Anxiety
What research shows about ashwagandha - let's look at the standardized forms and data
Ashwagandha is an adaptogen studied for stress and anxiety. Clinical trials often use the standardized forms KSM-66 and Sensoril. Let's look at what the data show.
Ashwagandha is studied for its effect on cortisol - the stress hormone. Let's look at the mechanism, forms and data.
What is ashwagandha
Ashwagandha (Withania somnifera) is a plant used in Ayurveda. It is considered an adaptogen - a substance that helps adapt to stress.
Mechanism
The mechanism of ashwagandha is linked to the stress axis.
KSM-66 and Sensoril
KSM-66 and Sensoril are standardized ashwagandha extracts used in trials.
| Form | Feature |
|---|---|
| KSM-66 | Root extract, withanolide standardization |
| Sensoril | Root and leaf extract |
Cortisol and stress
Ashwagandha is studied for its effect on cortisol and stress.
Trial data
What clinical trials show.
| Indicator | What is shown |
|---|---|
| Cortisol | Lower in several studies |
| Anxiety | Improved scores |
| Sleep | Improved |
Limits
It is important to understand the limits of the data.
What matters
How to sensibly approach ashwagandha.
Understand the data
Ashwagandha is studied for lowering cortisol and anxiety.
Choose the forms
KSM-66 and Sensoril are standardized forms from trials.
Follow the doses
In trials, usually 300-600 mg/day. Follow the instructions.
Consider contraindications
Ashwagandha may affect the thyroid and medications. Consult a doctor. More in the article on adaptogens.
What is ashwagandha?
An adaptogen from Ayurveda. It is studied for effects on stress, cortisol and anxiety.
What are KSM-66 and Sensoril?
Standardized ashwagandha extracts used in clinical trials.
Does ashwagandha lower cortisol?
Some studies show lower cortisol. The effect is moderate.
Does it help with anxiety?
Several studies show improved anxiety scores. The data are mixed.
How much to take?
In trials, usually 300-600 mg of standardized extract per day.
Is ashwagandha safe?
At recommended doses usually yes. It may affect the thyroid and medications - a doctor.
Does it replace treatment?
No. With anxiety - a comprehensive approach and a doctor. Ashwagandha is support.
How does it work?
It affects the HPA axis and withanolides. It may lower cortisol.
Are there limits to the data?
Yes, many studies are small and short. The effect is moderate.
Who is it contraindicated for?
With thyroid issues, pregnancy, medications - a doctor's consultation.