🧬 Sirtuins and NAD+: Anti-Aging Potential of SIRT1 and SIRT3
"Longevity genes" activated by fasting and exercise
"Longevity genes" are talked about more and more. We mean sirtuins — proteins that control cell function and depend on NAD+. Let's look at how it works.
What are sirtuins
Sirtuins are a family of proteins linked to the regulation of cell metabolism and aging. They are called "longevity genes."
- Family of proteins.
- Metabolism regulation.
- Link to aging.
- "Longevity genes."
NAD+
NAD+ is a coenzyme without which sirtuins don't work. Its level drops with age, which is linked to lower energy.
- Coenzyme.
- Needed by sirtuins.
- Drops with age.
- Lower energy.
SIRT1
SIRT1 affects metabolism and cell protection. It is activated by fasting and some plant compounds.
- Metabolism.
- Cell protection.
- Fasting activation.
- Plant compounds.
SIRT3
SIRT3 works inside mitochondria — the cell's "power plants." It helps them produce energy and reduce oxidative stress.
- Works in mitochondria.
- Cell energy.
- Reduces oxidative stress.
- Important for longevity.
How to activate
| Method | Mechanism |
|---|---|
| Fasting | Raises NAD+ |
| Exercise | Activates SIRT |
| Sleep | Recovery |
Practice
- Intermittent fasting.
- Regular exercise.
- Enough sleep.
- Plant food.
- Careful with NAD+ supplements.
- Consult a doctor.
What are sirtuins?
Proteins linked to cell metabolism and aging.
What is NAD+?
A coenzyme needed for sirtuins to work.
What does SIRT1 do?
Affects metabolism and cell protection.
What does SIRT3 do?
Supports mitochondrial energy.
How to activate sirtuins?
Fasting, exercise, sleep.
Do sirtuins help longevity?
Studied as a factor of cell resilience.
Are NAD+ supplements needed?
Data is mixed; lifestyle first.
What are mitochondria?
The cell's "power plants" that produce energy.
Does sleep affect sirtuins?
Yes, recovery matters.
When is a doctor needed?
With NAD+ supplements and chronic diseases.