The Complete Alphabet of Health: A Guide to All Vitamins from A to U

Encyclopedia of Nutrition Science

The Complete Alphabet of Health: A Guide to All Vitamins from A to U

Functions, roles and tasks — from retinol to S-methylmethionine

Vitamins are low-molecular-weight organic compounds that, in microscopic amounts, regulate virtually all biochemical processes in the body. They are not synthesized (or are synthesized insufficiently) endogenously and must come from food.

Below is a comprehensive guide to all known vitamins, grouped by solubility and biochemical kinship. For each compound we provide: key functions, daily intakes, food sources and deficiency symptoms.

Important note: Dosages are given for healthy adults (19–50 years). Requirements can change significantly during pregnancy, lactation, chronic disease and use of medications. Consult a doctor before taking high doses of any vitamin.

Top Vitamins People Need Most

Below is a summary table of the most significant vitamins for an adult. These are key substances whose deficiency is most common and easiest to correct. A detailed description of each is in the sections below.

Vitamin Key Role Daily Intake Best Sources
Vitamin D Bones, immunity, hormones 600–800 IU Cod liver oil, fatty fish, sunlight
Vitamin B12 Nervous system, blood formation 2.4 mcg Meat, fish, eggs, milk
Vitamin C Immunity, collagen, antioxidant 90 mg Citrus, kiwi, bell pepper
Vitamin B9 (folate) Cell division, DNA 400 mcg Leafy greens, legumes, liver
Vitamin A Vision, skin, immunity 700–900 mcg Liver, carrots, eggs, spinach
Vitamin B6 Metabolism, nervous system 1.3–1.7 mg Chicken, fish, potatoes, bananas
Vitamin E Antioxidant, cell membranes 15 mg Vegetable oils, nuts, seeds
Vitamin K Blood clotting, bones 90–120 mcg Green vegetables, broccoli, enzymes

🧈 Fat-Soluble Group (A, D, E, K)

Fat-soluble vitamins accumulate in the liver and fatty tissue, are excreted slowly, so uncontrolled intake can cause hypervitaminosis. Dietary fats are required for absorption.

Vitamin A (Retinol, Beta-Carotene)

Key functions: vision (rhodopsin), immunity of mucous membranes, cell differentiation, skin and epithelial health.
Parameter Value
Daily intake (men) 900 mcg RAE (retinol activity equivalent)
Daily intake (women) 700 mcg RAE
Tolerable upper level 3000 mcg/day (retinol)
Forms Retinol (animal sources), Beta-carotene (provitamin, plant sources)

Sources: liver, cod liver oil, egg yolk, butter; beta-carotene — carrots, pumpkin, spinach, sweet potato, apricots.

🩸 Test: Serum retinol
0.3 — 1.2 mg/L
Reference interval
Normal

Vitamin D (D2 — Ergocalciferol, D3 — Cholecalciferol)

Key functions: phosphorus-calcium metabolism, bone mineralization, innate immunity, hormonal regulation, modulation of cell division.
Parameter Value
Daily intake 600–800 IU (15–20 mcg)
Deficiency 25(OH)D < 20 ng/mL (50 nmol/L)
Insufficiency 25(OH)D 20–30 ng/mL
Optimum 30–60 ng/mL
Fact: Research shows that up to 60% of the population in some countries and 40% in Europe have vitamin D deficiency or insufficiency. The main cause is insufficient sun exposure and sunscreen use. Skin synthesis under UV-B provides about 80–90% of needs.

Vitamin E (Tocopherols and Tocotrienols)

The main fat-soluble antioxidant. Protects cell membranes from lipid peroxidation, supports reproductive function and immune response.

  • Active form: alpha-tocopherol
  • Daily intake: 15 mg (22.5 IU)
  • Sources: vegetable oils (sunflower, olive, wheat germ), nuts, seeds, spinach, avocado
  • Deficiency: rare; manifests as hemolytic anemia, peripheral neuropathy, myopathy

Vitamin K (K1 — Phylloquinone, K2 — Menaquinone)

Key functions: blood clotting (carboxylation of prothrombin), redirecting calcium from vessels into bone tissue (activation of osteocalcin and MGP — Matrix Gla Protein).
K1

Phylloquinone

Plant source. Provides ~90% of needs. Found in green leafy vegetables.

K2

Menaquinone (MK-4, MK-7)

Synthesized by intestinal microflora and found in fermented foods (natto). Longer half-life.

Daily intake: 90–120 mcg. Sources: spinach, cabbage (broccoli, Brussels sprouts), greens, liver, eggs, natto.

💧 Water-Soluble Group: B-Complex

B vitamins act as coenzymes in key metabolic reactions: energy metabolism, neurotransmitter synthesis, blood formation, DNA methylation. They do not accumulate in the body (except B12) and require regular intake.

Vitamin B1 (Thiamine)

Functions: carbohydrate metabolism, ATP synthesis, nerve impulse conduction (acetylcholine synthesis), heart function.

Intake: 1.1–1.2 mg. Sources: pork, whole grains, legumes, nuts, yeast.

Clinical example: Alcoholism is the leading cause of B1 deficiency in developed countries. Severe deficiency leads to Wernicke-Korsakoff syndrome (confusion, ataxia, ophthalmoplegia). Requires immediate parenteral thiamine administration.

Vitamin B2 (Riboflavin)

Functions: tissue respiration, flavoprotein function (FMN and FAD), skin and vision health, blood formation.

Intake: 1.1–1.3 mg. Sources: dairy products, eggs, liver, almonds, mushrooms.

Vitamin B3 (Niacin, Nicotinic Acid, Vitamin PP)

Functions: NAD/NADH synthesis for mitochondrial respiration, lipid profile regulation (lowering LDL, raising HDL), capillary dilation.

🩸 B3 status marker
3.0 — 5.5 umol/L
N-methylnicotinamide in urine
Normal

Intake: 14–16 mg (NE — niacin equivalent). Sources: meat, fish, poultry, peanuts, whole grains.

Side effect: Nicotinic acid in high doses (>50 mg) causes "niacin flush" — skin redness, burning and itching due to prostaglandin release. The safe form is niacinamide (does not cause flush).

Vitamin B5 (Pantothenic Acid)

Part of Coenzyme A (CoA) — a key metabolite of the Krebs cycle. Needed for fatty acid, cholesterol, steroid hormone and neurotransmitter acetylcholine synthesis.

Intake: 5 mg. Sources: almost all foods (from Greek "pantos" — everywhere), especially liver, eggs, avocado, mushrooms.

Vitamin B6 (Pyridoxine, Pyridoxal-5-Phosphate / P-5-P)

Key functions: protein metabolism, amino acid transamination, neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine), hemoglobin synthesis, glycogenolysis.
Parameter Value
Daily intake 1.3–1.7 mg
Upper limit (toxicity) 100 mg/day (sensory neuropathy)
Active form in supplements Pyridoxal-5-Phosphate (P-5-P)

Sources: poultry, fish, liver, potatoes, bananas, chickpeas, whole grains.

Vitamin B7 (Biotin, Vitamin H)

Functions: carboxylation in fat and carbohydrate metabolism (gluconeogenesis, fatty acid synthesis), keratin synthesis (hair, skin and nail health).

Fact: Raw egg white contains avidin — a glycoprotein that binds biotin and prevents its absorption. Heat treatment denatures avidin. Deficiency requires consuming ~12–24 raw eggs per day over a long period.

Intake: 30 mcg. Sources: liver, eggs (yolk), nuts, seeds, sweet potato, spinach.

Vitamin B9 (Folic Acid, Folates / 5-MTHF)

Key functions: one-carbon metabolism, DNA/RNA synthesis, cell division, erythropoiesis, prevention of fetal neural tube defects (spina bifida).
🩸 Test: Serum folates
7.0 — 46.4 nmol/L
Reference interval
Normal
Critically important: Women planning pregnancy are advised to take 400–800 mcg/day of folic acid at least 1 month before conception and during the first trimester. This reduces the risk of neural tube defects by 50–70%.

Intake: 400 mcg (DFE — dietary folate equivalent), during pregnancy — 600 mcg. Sources: liver, green leafy vegetables, legumes, citrus, fortified grains.

Vitamin B12 (Cobalamin: Methyl-, Adenosyl-, Cyanocobalamin)

Key functions: erythropoiesis, myelin sheath formation of nerve fibers, remethylation of homocysteine to methionine (together with folates).
Parameter Value
Daily intake 2.4 mcg
Absorption Requires intrinsic factor (gastric parietal cell secretion)
Blood norm 200–900 pg/mL
Optimal level > 400–500 pg/mL
Fact: B12 is synthesized exclusively by microorganisms. It is absent in plants. Vegans and strict vegetarians must take B12 supplements. Pernicious anemia (autoimmune damage to gastric parietal cells) requires lifelong parenteral B12.

🍊 Water-Soluble Group: Vitamin C and P

Vitamin C (Ascorbic Acid, Ascorbates)

Key functions: hydroxylation of proline and lysine in collagen synthesis, norepinephrine and carnitine synthesis, powerful antioxidant (neutralizes ROS), enhancement of phagocytosis and immune response, improvement of non-heme iron absorption.
  • Intake: 90 mg (men), 75 mg (women); smoking adds +35 mg/day
  • Upper limit: 2000 mg/day (osmotic diarrhea)
  • Sources: citrus, kiwi, bell pepper, broccoli, strawberries, blackcurrant, sea buckthorn
  • Heat lability: Destroyed when heated above 60°C and during prolonged storage
🩸 Test: Plasma ascorbic acid
23 — 85 umol/L
Adequate level
Normal < 11 umol/L — deficiency

Vitamin P (Bioflavonoids: Rutin, Quercetin, Hesperidin)

Functions: strengthening capillary walls, inhibition of hyaluronidase, protection of vitamin C from oxidation (synergism), antioxidant activity.

Sources: citrus (especially white pith and zest), buckwheat, green tea, onions, apples, berries.

Synergy: Bioflavonoids improve absorption and reduce oxidation of vitamin C. That is why they occur together in nature — nature created the perfect tandem. When taking synthetic vitamin C, it is advisable to also get flavonoids from plant food.

🔬 Vitamin-Like Substances (Conditional Vitamins)

These compounds are not vitamins in the strict sense (synthesized endogenously in sufficient amounts or have no proven avitaminosis), but have important biological functions and are often included in complex supplements.

Vitamin B4 (Choline)

Functions: precursor of acetylcholine (memory and attention neurotransmitter), phosphatidylcholine (structural component of cell membranes), methyl group donor (via betaine).

Intake: 425–550 mg. Sources: eggs (yolk — record holder), liver, soy, cauliflower.

Vitamin B8 (Inositol / Myo-Inositol)

Functions: secondary messenger in hormone signaling (insulin, FSH, TSH), receptor sensitivity support, cell membrane component (phosphatidylinositol).

Clinical application: Myo-inositol at 2–4 g/day is used in obstetrics and gynecology to improve insulin sensitivity in PCOS (polycystic ovary syndrome) and reduce the risk of gestational diabetes.

Vitamin B10 (PABA / Para-aminobenzoic Acid)

Functions: participation in folic acid synthesis by intestinal microflora, skin protection from UV radiation (part of sunscreens).

Vitamin B11 / BT (L-Carnitine)

Functions: transport of long-chain fatty acids into the mitochondrial matrix for beta-oxidation. Without carnitine, fat oxidation is impossible.

🩸 Test: Plasma L-Carnitine
36 — 82 umol/L
Free carnitine (normal)
Normal

Vitamin B13 (Orotic Acid)

Functions: participation in pyrimidine base synthesis (nucleic acids), tissue growth support, cardioprotective effect.

Vitamin B15 (Pangamic Acid)

Functions: improvement of tissue oxygen uptake, lipotropic effect (prevention of fatty liver infiltration).

Vitamin B17 (Amygdalin / Laetrile)

Important: Amygdalin (laetrile) is not a vitamin. Its promotion as an anticancer agent ("vitamin B17") is a dangerous pseudoscientific concept. Amygdalin metabolism releases cyanide, which can cause severe poisoning. FDA and EMA have not recommended its use. No quality clinical study has confirmed the effectiveness of amygdalin in oncology.

Vitamin N (Alpha-Lipoic / Thioctic Acid)

Functions: universal endogenous antioxidant (works in both aqueous and lipid environments), cofactor of mitochondrial multienzyme complexes (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase).

Application: In diabetic polyneuropathy — 600–1200 mg/day intravenously or orally (improves insulin sensitivity and reduces neuropathic pain).

Vitamin U (S-Methylmethionine)

Functions: methylmethionine sulfonium, stimulation of GI mucosal regeneration and healing, methyl group donor.

Discovery history: Vitamin U was discovered in the 1940s when researchers found that raw cabbage juice accelerates gastric ulcer healing. The active substance turned out to be S-methylmethionine. The name "U" comes from Latin ulcus — "ulcer".
❓ Frequently Asked Questions About Vitamins
Which vitamins are most important for the body?

All vitamins are important, but critical ones include vitamin D (deficiency in 60% of the population), vitamin B12 (especially for vegans), folic acid (B9) (for those planning pregnancy) and vitamin C (immunity, collagen). With a balanced diet, most vitamins come in sufficient amounts, but D and B12 require special attention.

Can I take all vitamins together?

Not all combinations are safe. For example, vitamin K and vitamin E in high doses can affect blood clotting. Calcium and iron compete for absorption. Fat-soluble vitamins (A, D, E, K) accumulate in the body — their overdose is more dangerous than water-soluble ones. Better to take complexes designed with compatibility in mind, or separate intake by time.

Which vitamins are needed for immunity?

Key vitamins for the immune system: vitamin D (regulates innate and adaptive immunity), vitamin C (antioxidant, supports phagocytosis), vitamin A (protection of mucous membranes), vitamin B6 (participates in immune cell synthesis) and zinc (mineral critical for immune response).

Which vitamins are absorbed better — synthetic or from food?

The body absorbs vitamins from food and synthetic analogs almost equally, but with nuances. Folic acid (synthetic B9) is absorbed better than natural folates. Vitamin E from supplements often contains only alpha-tocopherol, while food presents all 8 tocopherol forms. Beta-carotene from carrots is absorbed worse than retinol from liver. Food sources are preferable due to accompanying nutrients and synergy.

Can you overdose on vitamins?

Yes, especially fat-soluble vitamins (A, D, E, K), which accumulate in the liver and fatty tissue. Hypervitaminosis A can cause nausea, headaches and liver damage. Vitamin D overdose leads to hypercalcemia and kidney damage. Water-soluble vitamins (C, B-complex) are excreted in urine, but in very high doses (e.g., B6 > 100 mg/day) can cause neurological symptoms. Uncontrolled high-dose intake is dangerous.

Which tests should I take to check vitamin levels?

Basic minimum: 25(OH)D (vitamin D), vitamin B12 and folates (B9) in blood serum, ferritin (indirect iron marker) and homocysteine (marker of B9/B12/B6 deficiency). For deeper diagnosis: vitamin A (retinol), vitamin E (alpha-tocopherol), vitamin B6 (pyridoxal-5-phosphate) in plasma. A doctor should interpret the tests.

Is it necessary to take vitamin D in winter?

For most regions north of the 35th parallel — yes. From October to March, sunlight UV-B is insufficient for vitamin D synthesis in the skin. Recommended preventive dose: 800–2000 IU/day for adults. Before high doses, it is advisable to take a 25(OH)D test. In summer with regular sun exposure, intake can be paused.

Which vitamins do vegans need?

Strict vegans must take vitamin B12 (absent in plants) — at least 50–100 mcg/day of cyanocobalamin or 1000 mcg twice a week. It is also recommended to monitor vitamin D (if little sun), iron (non-heme absorbs worse), calcium and omega-3 (DHA/EPA) from microalgae. Iodine and zinc also require attention.

Does vitamin C really help with colds?

Regular vitamin C intake (200 mg/day) does not prevent colds, but can reduce their duration by 8–14% in adults and 18% in children according to a Cochrane review. High doses (1000–2000 mg/day) at the start of illness have not shown effectiveness. Vitamin C is most useful for people undergoing intense physical exertion (marathoners, skiers) — their cold risk is halved.

How do active forms of vitamins differ from regular ones?

Active forms are coenzyme forms that the body can use directly, without metabolic activation. Examples: pyridoxal-5-phosphate (P-5-P) instead of pyridoxine (B6), 5-methyltetrahydrofolate (5-MTHF) instead of folic acid (B9), methylcobalamin instead of cyanocobalamin (B12). Active forms are preferable for people with metabolic disorders (MTHFR mutations, liver disease). For healthy people the difference is insignificant.

Which vitamins affect hair and nail growth?

Biotin (B7) is the key vitamin for keratin synthesis, the structural protein of hair and nails. Also important: vitamin D (stimulates hair follicles), vitamin A (regulates cell renewal), iron (deficiency is a common cause of hair loss in women), zinc and omega-3. For nails, silicon and vitamin B7 are especially important. If there is no deficiency, additional doses will not speed up growth.

Why is vitamin D deficiency dangerous?

Chronic vitamin D deficiency is associated with osteoporosis (reduced bone mineral density), increased fall risk in the elderly, weakened immunity (frequent respiratory infections), autoimmune diseases (multiple sclerosis, type 1 diabetes), cardiovascular pathologies and depressive states. In children, severe deficiency causes rickets. A 25(OH)D level below 20 ng/mL is considered deficiency, 20–30 ng/mL — insufficiency.

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Vitamin D: The Sunshine Vitamin and Its Deficiency
Folic Acid (B9) vs L-Methylfolate (5-MTHF): Which Folate Form to Choose with an MTHFR Variant