Chronic Inflammation with Aging (Inflammaging): Causes and Protocols

Longevity

🔥 Chronic Inflammation with Aging (Inflammaging): Causes and Protocols

How to control age-related inflammation

Inflammaging is chronic low-grade systemic inflammation that increases with age. Let's look at causes, mechanisms and correction protocols.

🔬 What is inflammaging

Inflammaging is a combination of "inflammation" and "aging". It is chronic low-grade inflammation that accelerates age-related diseases.

  • Chronic inflammation.
  • Low grade.
  • Increases with age.
  • Accelerates diseases.
Read also: about bioage markers — "Biological age markers".

⚙️ Mechanisms

Key factors are senescent cells, oxidative stress, microbiome changes and accumulation of pro-inflammatory signals.

  • Senescent cells.
  • Oxidative stress.
  • Dysbiosis.
  • Pro-inflammatory cytokines.
Read also: about senescent cells — "Theories of aging".

🩸 Markers

MarkerLevel
hsCRPBelow 1 mg/l — ideal
FibrinogenWithin normal range
Interleukin-6Low

🥗 Nutrition

  • Mediterranean diet.
  • More vegetables and fish.
  • Less sugar and trans fats.
  • Antioxidants.
Read also: about fats — "Saturated fats and cholesterol".

💊 Supplements

  • Omega-3 (EPA/DHA).
  • Curcumin.
  • Vitamin D.
  • Antioxidants.
Read also: about curcumin — "Curcumin: forms and bioavailability".

😴 Lifestyle

  • Quality sleep.
  • Regular exercise.
  • Stress management.
  • No smoking.

💡 Protocol

  • Check hsCRP and fibrinogen.
  • Omega-3: 1–2 g EPA/DHA/day.
  • Curcumin: 500–1000 mg/day.
  • Control weight and sleep.
  • Consult a doctor.
Tip: lowering hsCRP is a marker of effectiveness.
❓ FAQ
What is inflammaging?

Chronic low-grade systemic inflammation that increases with age.

Why does inflammation occur with aging?

Due to senescent cells, oxidative stress and dysbiosis.

How to check inflammation level?

By hsCRP, fibrinogen and interleukin-6.

What reduces inflammation?

Nutrition, omega-3, curcumin, sleep, movement.

Which diet is anti-inflammatory?

Mediterranean: vegetables, fish, olive oil.

Does omega-3 help?

Yes, EPA/DHA lower pro-inflammatory markers.

Normal hsCRP level?

Ideally below 1 mg/l; 1–3 is moderate risk.

Is inflammation reversible?

Yes, lifestyle correction lowers its level.

Is high hsCRP dangerous?

Yes, associated with cardiovascular disease risk.

When to see a doctor?

With persistent high hsCRP and accompanying symptoms.

Geroscience: Disease as Ageing or Ageing as Disease — a New Longevity Paradigm
Omega-3 Fatty Acids for Heart Health and Healthy Aging
Spermidine: Activating Autophagy and Extending Healthy Life