Mechanism of Adaptogens: The Hypothalamic-Pituitary-Adrenal (HPA) Axis

Biochemistry and mechanisms

🔬 Mechanism of Adaptogens: The Hypothalamic-Pituitary-Adrenal (HPA) Axis

How herbal adaptogens help the body cope with stress

Adaptogens are plants that help the body adapt to stress and normalise physiological processes. Their action is largely linked to the hypothalamic-pituitary-adrenal (HPA) axis — the main stress-response system that regulates cortisol production.

🌿 What are adaptogens

The term "adaptogen" was proposed in 1947 by the Soviet scientist Nikolai Lazarev. Adaptogens increase non-specific resistance to stress, helping to maintain homeostasis. They include ashwagandha, rhodiola, ginseng, eleutherococcus and schisandra.

  • Increase resistance to stress.
  • Normalise physiological processes.
  • Act under moderate and chronic stress.
  • Studied for their effect on cortisol.
Fact: the term "adaptogen" was proposed in 1947, but the plants themselves have been used in traditional medicine for thousands of years.

🧬 HPA axis and cortisol

The HPA axis is a cascade: hypothalamus → pituitary → adrenal glands. Under stress it triggers the production of cortisol, the main "stress hormone". Chronic stress can disrupt the axis, and adaptogens are studied for their ability to normalise it.

StepOrganFunction
1HypothalamusReleases CRH
2PituitaryReleases ACTH
3Adrenal glandsProduce cortisol
Key: adaptogens may affect cortisol regulation, helping to "smooth out" the response to chronic stress.

Ashwagandha

Ashwagandha (Withania somnifera) is one of the most studied adaptogens. Its active compounds are withanolides. RCTs show a reduction in cortisol and anxiety in people with chronic stress.

  • Contains withanolides.
  • Lowers cortisol in studies.
  • Reduces anxiety.
  • Popular as a standardised extract (KSM-66).
Read also: clinical trials of ashwagandha KSM-66 and Sensoril — "Ashwagandha: KSM-66 and Sensoril".

🌸 Rhodiola rosea

Rhodiola rosea is known as an adaptogen that boosts energy and resistance to fatigue. Its active compounds are rosavins and salidroside. It is studied for its effect on fatigue and stress.

  • Contains rosavins and salidroside.
  • Boosts energy and endurance.
  • Reduces fatigue.
  • Studied under stress.
Use: rhodiola is often used for fatigue, stress and reduced performance.

🧪 Ginseng

Ginseng (Panax ginseng) is a classic adaptogen whose active compounds are ginsenosides. It is studied for its tonic effect and energy support.

  • Contains ginsenosides.
  • Tonic and energy support.
  • Studied for effect on fatigue.
  • Used in traditional medicine.
Note: the effects of ginseng depend on the species (Panax, Siberian) and extract standardisation.

📊 Norms and dosages

AdaptogenTypical doseComment
Ashwagandha300–600 mg/dayStandardised
Rhodiola200–400 mg/day3% rosavins
Ginseng200–400 mg/dayStandardised
Monthly stock: jars of standardised extracts usually last 1–2 months of a course per the label.

💡 Practice

  • Choose standardised extracts with stated active compounds.
  • Start with the minimum dose.
  • Take in courses, usually 4–8 weeks.
  • Adaptogens supplement stress management and sleep.
  • Do not combine with medicines without a doctor.
Important: during pregnancy, medicine use and chronic conditions, adaptogens require a doctor's consultation.
❓ FAQ
What are adaptogens?

Plants that help the body adapt to stress and normalise physiological processes.

What is the HPA axis?

The hypothalamus → pituitary → adrenal cascade that regulates cortisol production under stress.

How does ashwagandha lower cortisol?

RCTs show a cortisol reduction through the action of withanolides on stress regulation.

What does rhodiola contain?

Rosavins and salidroside — active compounds that support energy and resistance to fatigue.

What does ginseng contain?

Ginsenosides — active compounds with a tonic effect.

How much ashwagandha to take?

Usually 300–600 mg of standardised extract a day, per the label.

How much rhodiola to take?

Usually 200–400 mg of extract with 3% rosavins a day.

How long to take?

In courses of 4–8 weeks, with breaks, as recommended.

Who should not take adaptogens?

Pregnant women and those on medicines, especially with chronic conditions, need a consultation.

Do adaptogens replace sleep?

No, they supplement stress management but do not replace sleep and a healthy lifestyle.

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