Clinical Research & Meta-Analyses Reviews
Stress and cortisol affect vessels and the heart. Let's look at the mechanisms and the role of coenzyme Q10 in protecting the cardiovascular system.
Collagen peptides are a popular supplement for the skin. We look at what double-blind placebo studies show about their effect on wrinkles, elasticity and hydration.
Senolytics — a class of agents that selectively destroy senescent ("zombie") cells. We review dasatinib+quercetin and fisetin research and what is already known in humans.
Creatine and D-aspartic acid: comparison for strength, endurance and hormones. Let's look at mechanisms, what to choose and dosages.
Methylation and genes: how the body switches DNA on and off, the role of B12, folate and MTHFR. Let's look at food sources and practice.
Glucosamine & Chondroitin: why research results are conflicting. Role for joints, data, dosages and limits.
Resveratrol and NR/NMN: from David Sinclair's mouse experiments to human trials. Let's look at the NAD+ mechanisms, sirtuins and evidence.
Clinical trials of Ashwagandha (KSM-66 / Sensoril): effects on cortisol and anxiety. Mechanism, data and limits.
Magnesium L-threonate: research on the blood-brain barrier, memory and the Alzheimer's model. Mechanism, data and limits.
L-theanine + caffeine: how the combination gives calm focus without jitter. Let's look at the mechanisms, ratio and food sources.
Glucosamine and Chondroitin for joints: why research results are contradictory. Let's look at osteoarthritis, meta-analyses and dosages.
Lion's Mane mushroom: what research shows about NGF and BDNF. Mechanism, effects on the nervous system, cognition and limits of data.
Creatine beyond muscles: how it affects cognitive function in older adults. Mechanisms, research, the role for brain and memory, dosages and safety.
Omega-3 and the brain: what research shows about memory, cognitive health and mood. The role of EPA/DHA, data and limits.
Vitamin B12 and folate: why deficiency builds up for years, homocysteine and the MTHFR mutation. Let's look at effects on vessels and tests.
Curcumin and bioavailability: what research shows for inflammation and pain. Which forms are studied, mechanisms, dosages, limits of evidence.
Estrogen and phytoestrogens: the role of soy isoflavones (genistein, daidzein) in women's health. Let's look at research data and food sources.
N-acetylcysteine (NAC) is studied in randomised clinical trials for obsessive-compulsive disorder and depression. We break down the mechanisms and data.
Vitamin K2 (MK-7) in the prevention of vascular calcification: Rotterdam Study data. Let's look at its role in heart and vessel health.
The VITAL trial: a large randomized study of vitamin D and Omega-3 for the prevention of cancer and cardiovascular disease. Design, key results, limitations and what it means in practice.
Analysis of current scientific publications. Translations and adaptations of key studies from leading peer-reviewed journals.
Critical evaluation of the evidence base with study quality assessment.